Structure of PDB 5een Chain B

Receptor sequence
>5eenB (length=353) Species: 7955 (Danio rerio) [Search protein sequence]
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPA
RLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTC
ALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAAL
TARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGA
FFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAR
EFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIIL
EGGYNLTSISESMSMCTSMLLGDSPPSLPLKTSATVSINNVLRAHAPFWS
SLR
3D structure
PDB5een Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
ChainB
Resolution1.861 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D612 H614 D705 D171 H173 D264
BS02 5OG B P464 S531 H573 H574 F583 D612 H614 F643 L712 Y745 P23 S90 H132 H133 F142 D171 H173 F202 L271 Y304 PDBbind-CN: -logKd/Ki=8.96,Ki=1.1nM
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