Structure of PDB 5ebt Chain B

Receptor sequence
>5ebtB (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
MTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAMF
GAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGK
SFLQFSTIKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITY
QIMKPE
3D structure
PDB5ebt Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
ChainB
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5N8 B H1184 G1185 F1188 F1197 D1198 H1201 A1202 F1208 I1212 Y1213 K1220 S1221 Y1224 E1291 H80 G81 F84 F93 D94 H97 A98 F100 I104 Y105 K112 S113 Y116 E183
BS02 ZN B C1234 H1237 C1242 C1245 C126 H129 C134 C137
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5ebt, PDBe:5ebt, PDBj:5ebt
PDBsum5ebt
PubMed26546219
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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