Structure of PDB 5e9s Chain B

Receptor sequence

>5e9sB (length=427) Species: 311400 (Thermococcus kodakarensis)

LLRRYLDYPVLWKILWGLVLGAVFGLIAGHFGYAGAVKTYIKPFGDLFVR
LLKMLVMPIVLASLVVGAASISPARLGRVGVKIVVYYLATSAMAVFFGLI
VGRLFNVGANVNLGSGTGKAIEAQPPSLVQTLLNIVPTNPFASLAKGEVL
PVIFFAIILGIAITYLMNRNEERVRKSAETLLRVFDGLAEAMYLIVGGVM
QYAPIGVFALIAYVMAEQGVRVVGPLAKVVGAVYTGLFLQIVITYFILLK
VFGIDPIKFIRKAKDAMITAFVTRSSSGTLPVTMRVAEEEMGVDKGIFSF
TLPLGATINMDGTALYQGVTVLFVANAIGHPLTLGQQLVVVLTAVLASIG
TAGVPGAGAIMLAMVLQSVGLDLTPGSPVALAYAMILGIDAILDMGRTMV
NVTGDLAGTVIVAKTEKELDESKWISH

3D structure

• PDB: 5e9s Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk.
• Chain: B
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ASP	B	R278 S279 S280 M314 T317 T355 A356 V358 A361 G362 R401 T402 N405	R274 S275 S276 M310 T313 T351 A352 V354 A357 G358 R397 T398 N401
BS02	NA	B	T311 I312 M314 S352 I353 G354 T355	T307 I308 M310 S348 I349 G350 T351
BS03	NA	B	S280 G309 A310 N313 N405 V406 D409	S276 G305 A306 N309 N401 V402 D405
BS04	NA	B	Y91 T94 S95 N313 D315	Y87 T90 S91 N309 D311
BS05	DMU	B	L198 G201 G202 Q205 E293	L194 G197 G198 Q201 E289

Gene Ontology

Molecular Function

• GO:0015293 symporter activity

Biological Process

• GO:0046942 carboxylic acid transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5e9s, PDBe:5e9s, PDBj:5e9s
• PDBsum: 5e9s
• PubMed: 27830699
• UniProt: Q5JID0