Structure of PDB 5e8j Chain B

Receptor sequence
>5e8jB (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
SRIFYLRNFNNWMKSVLIGEFLEKVRQKKKRDITVLDLGCGKGGDLLKWK
KGRINKLVCTDIADVSVKQCQQRYEDMKNRRDSEYIFSAEFITADSSKEL
LIDKFRDPQMCFDICSCQFVCHYSFESYEQADMMLRNACERLSPGGYFIG
TTPNSFELIRRLEASETESFGNEIYTVKFQKKGDYPLFGCKYDFNLEGVV
DVPEFLVYFPLLNEMAKKYNMKLVYKKTFLEFYEEKIKNNENKMLLKRMQ
ALEPYPANESSKLVSEKVDDYEHAAKYMKNSQVRLPLGTLSKSEWEATSI
YLVFAFEKQQ
3D structure
PDB5e8j Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B K180 G205 C206 D227 I228 Q284 F285 Y289 M300 K14 G39 C40 D61 I62 Q118 F119 Y123 M134
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5e8j, PDBe:5e8j, PDBj:5e8j
PDBsum5e8j
PubMed27422871
UniProtO43148|MCES_HUMAN mRNA cap guanine-N7 methyltransferase (Gene Name=RNMT)

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