Structure of PDB 5e6c Chain B

Receptor sequence
>5e6cB (length=72) Species: 9606 (Homo sapiens) [Search protein sequence]
KLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKI
RRKNCPACRYRKCLQAGMNLEA
3D structure
PDB5e6c Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B S440 R470 S22 R52 PDBbind-CN: Kd=67.9uM
BS02 ZN B C457 C463 C473 C476 C39 C45 C55 C58
BS03 ZN B C421 C424 C438 C441 C3 C6 C20 C23
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5e6c, PDBe:5e6c, PDBj:5e6c
PDBsum5e6c
PubMed29626214
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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