Structure of PDB 5e5g Chain B

Receptor sequence
>5e5gB (length=456) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MNWTVDIPIPPLPTDLRTRLDAALAKPAAQQPTWPADQALAMRTVLESVP
PVTVPSEIVRLQEQLAQVAKGEAFLLQGGDCAETFMDNTEPHIRGNVRAL
LQMAVVLTYGASMPVVKVARIAGQYAKPRSADIDALGLRSYRGDMINGFA
PDAAAREHDPSRLVRAYANASAAMNLVRALTSSGLASLHLVHDWNREFVR
TSPAGARYEALATEIDRGLRFMSACGVADRNLQTAEIYASHEALVLDYER
AMLRLSDGDDGEPQLFDLSAHTVWIGERTRQIDGAHIAFAQVIANPVGVK
LGPNMTPELAVEYVERLDPHNKPGRLTLVSRMGNHKVRDLLPPIVEKVQA
TGHQVIWQCDPMHGNTHESSTGFKTRHFDRIVDEVQGFFEVHRALGTHPG
GIHVEITGENVTECLGGAQDISETDLAGRYETACDPRLNTQQSLELAFLV
AEMLRD
3D structure
PDB5e5g Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTR B W3 V55 Y173 A174 W3 V49 Y167 A168 MOAD: Kd=700uM
PDBbind-CN: -logKd/Ki=3.15,Kd=700uM
BS02 MN B C87 H369 E411 D441 C81 H363 E405 D435
BS03 DTR B F91 R171 A174 N175 F85 R165 A168 N169 MOAD: Kd=700uM
PDBbind-CN: -logKd/Ki=3.15,Kd=700uM
BS04 DTR B L107 K123 A192 L194 N237 L101 K117 A186 L188 N231 MOAD: Kd=700uM
PDBbind-CN: -logKd/Ki=3.15,Kd=700uM
Gene Ontology
Molecular Function
GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0051260 protein homooligomerization
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5e5g, PDBe:5e5g, PDBj:5e5g
PDBsum5e5g
PubMed27128682
UniProtO53512|AROG_MYCTU Phospho-2-dehydro-3-deoxyheptonate aldolase AroG (Gene Name=aroG)

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