Structure of PDB 5dxe Chain B

Receptor sequence
>5dxeB (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LSLTADQMVSALLDAEPPILYSEYFSEASMMGLLTNLADRELVHMINWAK
RVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR
NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTKD
HIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGME
HLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5dxe Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 L372 V376 E380 E542 I46 L60 V64 E68 E219
BS02 EST B E353 L387 F404 H524 L525 E41 L75 F92 H201 L202 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5dxe, PDBe:5dxe, PDBj:5dxe
PDBsum5dxe
PubMed26928945
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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