Structure of PDB 5dxb Chain B

Receptor sequence
>5dxbB (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYFSEASMMGLLTNLADRELVHMINWA
KRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLD
RNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTD
HIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGME
HLYSMKCKNVPLSDLLLEMLDAHR
3D structure
PDB5dxb Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.
ChainB
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 L372 V376 E380 E542 M543 I47 L61 V65 E69 E218 M219
BS02 EST B E353 L387 G521 H524 E42 L76 G198 H201 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:5dxb, PDBe:5dxb, PDBj:5dxb
PDBsum5dxb
PubMed26928945
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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