Structure of PDB 5dw1 Chain B

Receptor sequence
>5dw1B (length=110) Species: 9606 (Homo sapiens) [Search protein sequence]
LSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMD
LSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDV
FEFRYAKMPD
3D structure
PDB5dw1 RVX-297- a novel BD2 selective inhibitor of BET bromodomains.
ChainB
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GD B P371 F372 V376 L383 N429 H433 V435 P26 F27 V31 L38 N84 H88 V90 MOAD: ic50=0.08uM
External links
PDB RCSB:5dw1, PDBe:5dw1, PDBj:5dw1
PDBsum5dw1
PubMed27282480
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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