Structure of PDB 5duh Chain B

Receptor sequence
>5duhB (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB5duh Predictive features of ligand-specific signaling through the estrogen receptor.
ChainB
Resolution2.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E380 D538 L539 E542 I52 K56 L66 V70 E74 D222 L223 E226
BS02 5FT B L346 T347 A350 E353 L384 L387 F404 M421 I424 L428 G521 H524 L525 L40 T41 A44 E47 L78 L81 F98 M115 I118 L122 G205 H208 L209 BindingDB: EC50=12nM
External links
PDB RCSB:5duh, PDBe:5duh, PDBj:5duh
PDBsum5duh
PubMed27107013
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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