Structure of PDB 5dug Chain B

Receptor sequence
>5dugB (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5dug Predictive features of ligand-specific signaling through the estrogen receptor.
ChainB
Resolution2.252 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 L372 E380 E542 M543 I54 L68 E76 E228 M229
BS02 5FV B M343 L346 T347 A350 E353 L384 F404 M421 I424 F425 G521 L525 M528 M39 L42 T43 A46 E49 L80 F100 M117 I120 F121 G207 L211 M214 BindingDB: EC50=0.14nM
External links
PDB RCSB:5dug, PDBe:5dug, PDBj:5dug
PDBsum5dug
PubMed27107013
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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