Structure of PDB 5dsg Chain B

Receptor sequence

>5dsgB (length=399) Species: 9606,10665

HNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFS
LACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL
LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQF
VVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASR
SRVNIFEMLRIDEGDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRR
AALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRA
KRVITTFRTGTWDAYQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNT
FCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYR

3D structure

• PDB: 5dsg Crystal structures of the M1 and M4 muscarinic acetylcholine receptors.
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): E1011
• Catalytic site (residue number reindexed from 1): E213
• Enzyme Commision number: 3.2.1.17: lysozyme.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0HK	B	Y113 S116 N117 W164 T196 T199 A200 W413 Y416 N417 Y439 C442 Y443	Y90 S93 N94 W141 T173 T176 A177 W339 Y342 N343 Y365 C368 Y369

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0004930 G protein-coupled receptor activity
• GO:0016907 G protein-coupled acetylcholine receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0040012 regulation of locomotion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5dsg, PDBe:5dsg, PDBj:5dsg
• PDBsum: 5dsg
• PubMed: 26958838
• UniProt: P00720|ENLYS_BPT4 Endolysin (Gene Name=E);
  P08173|ACM4_HUMAN Muscarinic acetylcholine receptor M4 (Gene Name=CHRM4)