Structure of PDB 5dq8 Chain B

Receptor sequence
>5dq8B (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
ARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQAPPLESVDVRQIY
DKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGGFYGVSSQYESLEHMT
LTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKL
RQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHH
IYRLVRDV
3D structure
PDB5dq8 Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.
ChainB
Resolution2.305 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLF B S345 V347 K357 M379 C380 I408 F428 S105 V107 K117 M139 C140 I168 F188 MOAD: Kd=73uM
BS02 FLF B K277 K301 W303 E404 V427 K52 K76 W78 E164 V187 MOAD: Kd=73uM
External links
PDB RCSB:5dq8, PDBe:5dq8, PDBj:5dq8
PDBsum5dq8
PubMed26592798
UniProtQ15562|TEAD2_HUMAN Transcriptional enhancer factor TEF-4 (Gene Name=TEAD2)

[Back to BioLiP]