Structure of PDB 5d7d Chain B

Receptor sequence
>5d7dB (length=189) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
QVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEV
VIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTSSVVNALSQDLEVYV
HRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNY
ETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG
3D structure
PDB5d7d Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.
ChainB
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B N82 G83 T171 N63 G64 T129
BS02 MG B G208 H228 G166 H186
BS03 57X B N54 S55 E58 V79 D81 R84 G85 I86 P87 R144 T173 I175 N35 S36 E39 V60 D62 R65 G66 I67 P68 R102 T131 I133 BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5d7d, PDBe:5d7d, PDBj:5d7d
PDBsum5d7d
PubMed26487916
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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