Structure of PDB 5d7c Chain B

Receptor sequence
>5d7cB (length=186) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
QVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEV
VIEKDNWIKVTDNGRGIPVDIQGRPAVEVILTSSVVNALSQDLEVYVHRN
ETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETL
QQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG
3D structure
PDB5d7c Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.
ChainB
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57W B N54 S55 E58 V79 D81 R84 G85 I86 P87 R144 T173 N35 S36 E39 V60 D62 R65 G66 I67 P68 R99 T128 MOAD: ic50=0.14uM
BindingDB: IC50=140nM
BS02 MG B N82 G83 T171 N63 G64 T126
BS03 MG B G208 H228 G163 H183
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5d7c, PDBe:5d7c, PDBj:5d7c
PDBsum5d7c
PubMed26460684
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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