Structure of PDB 5d69 Chain B

Receptor sequence
>5d69B (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCR
SMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELP
GAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFRAFKS
LDKDGTGQIQVNIQEWLQLTMYS
3D structure
PDB5d69 Conformationally restricted calpain inhibitors.
ChainB
Resolution1.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F164 G187 I189
Catalytic site (residue number reindexed from 1) F69 G92 I94
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B A109 D112 E114 E119 A14 D17 E19 E24
BS02 CA B D152 D154 T156 K158 E163 D57 D59 T61 K63 E68
BS03 CA B D182 D184 S186 T188 E193 D87 D89 S91 T93 E98
BS04 CA B D137 D225 D227 N228 D42 D130 D132 N133
BS05 57T B V127 H131 K172 Q175 V32 H36 K77 Q80
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5d69, PDBe:5d69, PDBj:5d69
PDBsum5d69
PubMed28757975
UniProtP04632|CPNS1_HUMAN Calpain small subunit 1 (Gene Name=CAPNS1)

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