Structure of PDB 5d11 Chain B

Receptor sequence
>5d11B (length=255) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLFLQEAQVMK
KLRHEKLVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVD
MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLFPIKW
TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG
YRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQ
PGENL
3D structure
PDB5d11 Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D121 R123 A125 N126 D139 F146
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 56G B L273 G274 A293 E339 M341 G344 C345 L393 L17 G18 A37 E74 M76 G79 C80 L128
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5d11, PDBe:5d11, PDBj:5d11
PDBsum5d11
PubMed26275028
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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