Structure of PDB 5ctu Chain B

Receptor sequence
>5ctuB (length=192) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
GSVTALQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGY
ANQIEVVIEKDNWIKVTDNGRGIPVDIQGRPAVEVILTSSVVNALSQDLE
VYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTV
YNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEG
3D structure
PDB5ctu Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB.
ChainB
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 54X B S1 V2 T3 L5 N54 E58 D81 R84 G85 I86 P87 S2 V3 T4 L6 N41 E45 D68 R71 G72 I73 P74
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5ctu, PDBe:5ctu, PDBj:5ctu
PDBsum5ctu
PubMed26786695
UniProtP0A0K8|GYRB_STAAU DNA gyrase subunit B (Gene Name=gyrB)

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