Structure of PDB 5ctn Chain B

Receptor sequence
>5ctnB (length=232) Species: 1408 (Bacillus pumilus) [Search protein sequence]
SIAWSVDEFFKNREGTFVIQEVKEKSPWVYNKKRAKERFAPQSTFKVANA
LIGLQTGAVRDEYDIKYWDGVKREIDNWNRDHTLGSGMRDSVVWYYQAMA
RDIGEERMNHWVKAIHYGNKDISGGIDQFWLSSTLRISPIEQVRFLKQLY
EETLPFDLKNMRTVKRMMVQEEEKHATLYGKTGSGSDIGWYVGFIKHEHK
TYILATNIKGTGIEAKDITYRILKKYHLMEAS
3D structure
PDB5ctn Class D beta-lactamases do exist in Gram-positive bacteria.
ChainB
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S101 K104 S149 Y154 W188 S242
Catalytic site (residue number reindexed from 1) S43 K46 S91 Y96 W130 S184
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5R7 B Q100 S101 W136 S149 V151 L189 G241 S242 Q42 S43 W78 S91 V93 L131 G183 S184
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
GO:0071555 cell wall organization

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Molecular Function
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Biological Process
External links
PDB RCSB:5ctn, PDBe:5ctn, PDBj:5ctn
PDBsum5ctn
PubMed26551395
UniProtA8FFI9

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