Structure of PDB 5cte Chain B

Receptor sequence
>5cteB (length=728) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
LRPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSAD
VKLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRG
RQFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARI
GMAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTER
TVINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVT
CRSVGIGAYLVRLGQRAIQVEGQPIILTGASALNKVLGREVYTSNLQLGG
TQIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDR
PVDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVV
GRARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQQAGQVWFPNSA
FKTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALV
DYKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPEG
TVEIKFRREKLLDTMNRLDDKYRELRQLADRERELLPIYGQISLQFADLH
DRSSRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHASRLEK
IARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGLKLESFAQDLAKK
IRSDHDNAIDGLSEVTDDKEKLLKTLKL
3D structure
PDB5cte Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
ChainB
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57L B R1954 G1955 S1957 G1958 L2025 E2026 G2029 E2032 R475 G476 S478 G479 L546 E547 G550 E553 PDBbind-CN: -logKd/Ki=7.80,IC50=0.016uM
BS02 57L B T1757 A1761 L1762 T278 A282 L283 PDBbind-CN: -logKd/Ki=7.80,IC50=0.016uM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5cte, PDBe:5cte, PDBj:5cte
PDBsum5cte
PubMed26411795
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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