Structure of PDB 5ctc Chain B

Receptor sequence
>5ctcB (length=687) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
RPIATPYPVKEWLQPKRYKAHLMGTTYVYDFPELFRQASSSQWKNFSADV
KLTDDFFISNELIEDENGELTEVEREPGANAIGMVAFKITVKTPEYPRGR
QFVVVANDITFKIGSFGPQEDEFFNKVTEYARKRGIPRIYLAANSGARIG
MAEEIVPLFQVAWNDAANPDKGFQYLYLTSEGMETLKKFDKENSVLTERT
VINGEERFVIKTIIGSEDGLGVECLRGSGLIAGATSRAYHDIFTITLVTC
RSVGIGAYLVRLGQRAIQVEGQPIILTGASALNKVLGREVYTSNLQLGGT
QIMYNNGVSHLTAVDDLAGVEKIVEWMSYVPAKRNMPVPILETKDTWDRP
VDFTPTNDETYDVRWMIEGRETESGFEYGLFDKGSFFETLSGWAKGVVVG
RARLGGIPLGVIGVETRTVENLIPADPANPNSAETLIQQAGQVWFPNSAF
KTAQAINDFNNGEQLPMMILANWRGFSGGQRDMFNEVLKYGSFIVDALVD
YKQPIIIYIPPTGELRGGSWVVVDPTINADQMEMYADVNARAGVLEPEGT
VEIKFRREKLLDTMNRLDDKYRELLADRERELLPIYGQISLQFADLHDRS
SRMVAKGVISKELEWTEARRFFFWRLRRRLNEEYLIKRLSHQVASRLEKI
ARIRSWYPASVDHEDDRQVATWIEENYKTLDDKLKGL
3D structure
PDB5ctc Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.14: biotin carboxylase.
6.4.1.2: acetyl-CoA carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 57K B R1954 L2025 E2026 G2029 E2032 R474 L545 E546 G549 E552 PDBbind-CN: -logKd/Ki=6.35,IC50=0.45uM
Gene Ontology
Molecular Function
GO:0003989 acetyl-CoA carboxylase activity
GO:0016874 ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5ctc, PDBe:5ctc, PDBj:5ctc
PDBsum5ctc
PubMed26411795
UniProtQ00955|ACAC_YEAST Acetyl-CoA carboxylase (Gene Name=ACC1)

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