Structure of PDB 5cs3 Chain B

Receptor sequence
>5cs3B (length=173) Species: 9606 (Homo sapiens) [Search protein sequence]
NTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKA
FVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSY
KGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGG
PWCFTSNPEVRYEVCDIPQCSEV
3D structure
PDB5cs3 Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EP1 B F162 E183 W188 R197 Y198 V200 F126 E147 W152 R161 Y162 V164 PDBbind-CN: -logKd/Ki=2.15,Kd=7.0mM
External links
PDB RCSB:5cs3, PDBe:5cs3, PDBj:5cs3
PDBsum5cs3
PubMed30090230
UniProtP14210|HGF_HUMAN Hepatocyte growth factor (Gene Name=HGF)

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