Structure of PDB 5cpr Chain B

Receptor sequence
>5cprB (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
MSAKELCENDDLATSLVLDPYLGFQTHKMNRQEELKEVIERFKKDEHLEK
AFKCLTSGEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNR
YSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSV
MYSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKALRDIEPGEE
ISCYYGDGFFGENNEFCECYTCERRGTGAFKS
3D structure
PDB5cpr The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C275 C319 C321 C324 C173 C217 C219 C222
BS02 SAM B H98 Y203 S205 E206 G209 A210 F250 A269 F270 N272 H273 Y307 F312 C321 H27 Y101 S103 E104 G107 A108 F148 A167 F168 N170 H171 Y205 F210 C219
BS03 539 B G229 S251 V252 W264 A268 A269 F281 A289 Y307 G127 S149 V150 W162 A166 A167 F179 A187 Y205 MOAD: Kd=27.8nM
PDBbind-CN: -logKd/Ki=7.56,Kd=27.5nM
BindingDB: IC50=25nM
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5cpr, PDBe:5cpr, PDBj:5cpr
PDBsum5cpr
PubMed28114273
UniProtQ4FZB7|KMT5B_HUMAN Histone-lysine N-methyltransferase KMT5B (Gene Name=KMT5B)

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