Structure of PDB 5clw Chain B

Receptor sequence
>5clwB (length=645) Species: 9606 (Homo sapiens) [Search protein sequence]
DFQRRYKQFSQILKNIGENEGGIDKFSRGYESFGVHRCADGGLYCKEWAP
GAEGVFLTGDFNGWNPFSYPYKKLDYGKWELYIPPKQNKSVLVPHGSKLK
VVITSKSGEILYRISPWAKYVVREGDNVNYDWIHWDPEHSYEFKHSRPKK
PRSLRIYESHVGISSHEGKVASYKHFTCNVLPRIKGLGYNCIQLMAIMEH
AYYASFGYQITSFFAASSRYGSPEELQELVDTAHSMGIIVLLDVVHSHAS
KNSADGLNMFDGTDSCYFHSGPRGTHDLWDSRLFAYSSWEVLRFLLSNIR
WWLEEYRFDGFRFDGVTSMLYHHHEYFGLQVDEDALTYLMLANHLVHTLC
PDSITIAEDVSGMPALCSPISQGGGGFDYRLAMAIPDKWIQLLKEFKDED
WNMGDIVYTLTNRRYLEKCIAYAESHDQALVGDKSLAFWLMDAEMYTNMS
VLTPFTPVIDRGIQLHKMIRLITHGLGGEGYLNFMGNEFGHPEWLDFPRK
GNNESYHYARRQFHLTDDDLLRYKFLNNFDRDMNRLEERYGWLAAPQAYV
SEKHEGNKIIAFERAGLLFIFNFHPSKSYTDYRVGTALPGKFKIVLDSDA
AEYGGHQRLDHSTDFFSEAFEHNGRPYSLLVYIPSRVALILQNVD
3D structure
PDB5clw Crystal structure of human glycogen branching enzyme (GBE1) in complex with maltoheptaose
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.18: 1,4-alpha-glucan branching enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B P93 G120 P50 G77
BS02 GLC B W91 Y119 W48 Y76
BS03 GLC B Y119 K121 W332 E333 Y76 K78 W289 E290
BS04 GLC B N62 E63 Y119 N19 E20 Y76
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003844 1,4-alpha-glucan branching enzyme activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0043169 cation binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006091 generation of precursor metabolites and energy
GO:0043524 negative regulation of neuron apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5clw, PDBe:5clw, PDBj:5clw
PDBsum5clw
PubMed
UniProtQ04446|GLGB_HUMAN 1,4-alpha-glucan-branching enzyme (Gene Name=GBE1)

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