Structure of PDB 5cfq Chain B

Receptor sequence
>5cfqB (length=179) Species: 45351 (Nematostella vectensis) [Search protein sequence]
NVADGLAWSYYFGYLKFVLPELEKQIEKTSKFRSKEKFVKKMFILIPSNC
FWDDKIPGSDYDPQNRITFEGNTEPLEKTRGGVFLRHYKHSVYEIKDGEN
EPWFCIMEYATPLLTLYDMSVAQPGELSREERDAQVVVFLRKLQDILEGD
RACQGKYELVTFSPDRDLADVMLRKLKDS
3D structure
PDB5cfq Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
ChainB
Resolution2.099 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SY B G205 Y206 R278 Y280 T303 G13 Y14 R86 Y88 T111 MOAD: Kd<1nM
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:5cfq, PDBe:5cfq, PDBj:5cfq
PDBsum5cfq
PubMed26300263
UniProtA7SLZ2|STING_NEMVE Stimulator of interferon genes protein (Gene Name=v1g246111)

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