Structure of PDB 5cc0 Chain B

Receptor sequence
>5cc0B (length=72) Species: 32630 (synthetic construct) [Search protein sequence]
QKVCLICGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRLRKCLQAGMTLG
3D structure
PDB5cc0 Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainB
Resolution2.405 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B S440 R447 R470 K471 R477 S23 R30 R53 K54 R60 PDBbind-CN: Kd=0.369uM
BS02 dna B G430 C431 H432 Y433 K446 G13 C14 H15 Y16 K29 PDBbind-CN: Kd=0.369uM
BS03 ZN B C421 C424 C438 C441 C4 C7 C21 C24
BS04 ZN B C457 C463 C473 C476 C40 C46 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cc0, PDBe:5cc0, PDBj:5cc0
PDBsum5cc0
PubMed26715749
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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