Structure of PDB 5c03 Chain B

Receptor sequence
>5c03B (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
SFHRVDQKEITQLSHLGQGTRTNVYEGRLRELRVVLKVLDPSHHDIALAF
YETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGH
VPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFI
KLSDPGVGLGALSREERVERIPWLAPECLPLSTAMDKWGFGATLLEICFD
GEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFR
TILRDLTRLQ
3D structure
PDB5c03 Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N734 R738 N739 D759
Catalytic site (residue number reindexed from 1) N129 R133 N134 D154
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AGS B G598 T599 T601 V603 V640 K642 E688 Y689 V690 P694 R738 L741 P760 G19 T20 T22 V24 V35 K37 E83 Y84 V85 P89 R133 L136 P155 MOAD: Kd=15uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5c03, PDBe:5c03, PDBj:5c03
PDBsum5c03
PubMed26359499
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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