Structure of PDB 5byf Chain B

Receptor sequence
>5byfB (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
EVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCVQAA
RLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIV
NNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEA
LTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGS
AADAGEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVD
TTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPY
KKDLPLTLFLEH
3D structure
PDB5byf Crystal structure of human ribokinase in complex with AMP
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G266 A267 G268 D269
Catalytic site (residue number reindexed from 1) G253 A254 G255 D256
Enzyme Commision number 2.7.1.15: ribokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B T235 G237 A238 A267 G268 N295 A298 T222 G224 A225 A254 G255 N282 A285
Gene Ontology
Molecular Function
GO:0004747 ribokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006014 D-ribose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0006753 nucleoside phosphate metabolic process
GO:0016310 phosphorylation
GO:0019303 D-ribose catabolic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5byf, PDBe:5byf, PDBj:5byf
PDBsum5byf
PubMed
UniProtQ9H477|RBSK_HUMAN Ribokinase (Gene Name=RBKS)

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