Structure of PDB 5buu Chain B

Receptor sequence
>5buuB (length=254) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKL
TIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITYVREEVIDFS
KPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIA
VFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQR
KPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLSEQGLLDKLKNK
WWYD
3D structure
PDB5buu Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4V6 B K493 P494 S754 K101 P102 S239
BS02 4V6 B I481 P494 S497 K730 G731 I89 P102 S105 K215 G216
BS03 GLU B Y450 L479 T480 R485 G653 S654 T655 E705 Y58 L87 T88 R93 G138 S139 T140 E190
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5buu, PDBe:5buu, PDBj:5buu
PDBsum5buu
PubMed26771108
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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