Structure of PDB 5btr Chain B

Receptor sequence
>5btrB (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPE
TIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIV
LTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRP
FFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQR
IIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMK
PEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHE
VPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQY
LFLPPNRYIFHGAEVY
3D structure
PDB5btr Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
ChainB
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P113 D114 F115 R116 N188 D190 H205
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B N226 H363 V412 F414 G415 E416 L418 R446 N68 H205 V254 F256 G257 E258 L260 R288
BS02 peptide B D150 P180 D9 P22
BS03 ZN B C374 C395 C398 C216 C237 C240
BS04 STL B R274 D292 Q294 A295 D298 F414 K444 R116 D134 Q136 A137 D140 F256 K286 BindingDB: EC50=46200nM
BS05 STL B Q222 G415 Q64 G257 BindingDB: EC50=46200nM
BS06 STL B L206 P211 I223 N226 E230 R446 P447 L48 P53 I65 N68 E72 R288 P289 BindingDB: EC50=46200nM
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5btr, PDBe:5btr, PDBj:5btr
PDBsum5btr
PubMed26109052
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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