Structure of PDB 5btn Chain B

Receptor sequence
>5btnB (length=245) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLM
ADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEF
AYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSV
RVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV
3D structure
PDB5btn Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
ChainB
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E459 D461 D536 E29 D31 D106
BS02 dna B K484 I486 N487 K490 R495 N499 H539 V656 R659 K54 I56 N57 K60 R65 N69 H109 V226 R229
BS03 dna B E459 D461 G483 K484 R492 D536 E29 D31 G53 K54 R62 D106
BS04 dna B K484 N487 K490 R495 N499 H539 R659 K54 N57 K60 R65 N69 H109 R229
BS05 MG B D532 D534 D102 D104
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5btn, PDBe:5btn, PDBj:5btn
PDBsum5btn
PubMed26792525
UniProtP9WG45|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)

[Back to BioLiP]