Structure of PDB 5bs8 Chain B

Receptor sequence

>5bs8B (length=245) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]

ALVRRKGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLM
ADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEF
AYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSV
RVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

3D structure

PDB

5bs8 Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.

Chain

Resolution

2.399 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	B	E459 D461 R492 D536	E29 D31 R62 D106
BS02	dna	B	K484 I486 N487 K490 R495 H539 V656 R659	K54 I56 N57 K60 R65 H109 V226 R229
BS03	dna	B	E459 D461 G483 R492 D536	E29 D31 G53 R62 D106
BS04	dna	B	K484 I486 N487 K490 R495 N499 H539 V656 R659	K54 I56 N57 K60 R65 N69 H109 V226 R229
BS05	MG	B	D532 D534	D102 D104

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006265	DNA topological change

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5bs8, PDBe:5bs8, PDBj:5bs8
PDBsum	5bs8
PubMed	26792525
UniProt	P9WG45\|GYRB_MYCTU DNA gyrase subunit B (Gene Name=gyrB)

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