Structure of PDB 5boo Chain B

Receptor sequence
>5booB (length=373) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
NPEFFLYDIFLKFCLKYIDGEICHDLFLLLGKYNILPYDTSNDSIYACTN
IKHLDFINPFGVAAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKP
RIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEEDKLLSKHIVGVS
IGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKLK
NIILSVKEEIDNLEKNNIMNDEFLWFNTTKKKPLVFVKLAPDLNQEQKKE
IADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAKLKDISTKFICE
MYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAVQ
IKRELNHLLYQRGYYNLKEAIGR
3D structure
PDB5boo A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G248 N274 F278 S345 N347 T348 K429 N458
Catalytic site (residue number reindexed from 1) G87 N113 F117 S184 N186 T187 K238 N267
Enzyme Commision number 1.3.5.2: dihydroorotate dehydrogenase (quinone).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D65 B L172 L176 G181 C184 H185 F188 F227 L240 I263 R265 I272 V532 M536 L11 L15 G20 C23 H24 F27 F66 L79 I102 R104 I111 V341 M345 BindingDB: IC50=10.0nM
BS02 FMN B A225 G226 T249 I263 N274 K429 S477 G478 S505 G506 G507 Y528 S529 A64 G65 T88 I102 N113 K238 S286 G287 S314 G315 G316 Y337 S338
Gene Ontology
Molecular Function
GO:0004152 dihydroorotate dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5boo, PDBe:5boo, PDBj:5boo
PDBsum5boo
PubMed26180101
UniProtQ08210|PYRD_PLAF7 Dihydroorotate dehydrogenase (quinone), mitochondrial (Gene Name=PFF0160c)

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