Structure of PDB 5bo9 Chain B

Receptor sequence
>5bo9B (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
WKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFS
ISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRC
NFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLD
GAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYW
KNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYY
DQLPAEFQLLYRMHGEGLTKLTLSHCA
3D structure
PDB5bo9 Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R298
Catalytic site (residue number reindexed from 1) R209
Enzyme Commision number 2.4.3.-
2.4.3.8: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL B F250 T252 R298 F161 T163 R209
BS02 SIA B N211 P212 S213 F249 R298 N122 P123 S124 F160 R209
BS03 CSF B N167 S168 C189 N190 N211 I214 S300 T301 G302 F321 W322 P323 Y336 H337 N78 S79 C100 N101 N122 I125 S211 T212 G213 F232 W233 P234 Y247 H248
Gene Ontology
Molecular Function
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5bo9, PDBe:5bo9, PDBj:5bo9
PDBsum5bo9
PubMed26192331
UniProtO43173|SIA8C_HUMAN Alpha-N-acetylneuraminate alpha-2,8-sialyltransferase ST8SIA3 (Gene Name=ST8SIA3)

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