Structure of PDB 5bmm Chain B

Receptor sequence
>5bmmB (length=275) Species: 9031 (Gallus gallus) [Search protein sequence]
AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFL
QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYL
RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA
RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTK
GRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPT
FEYLQAFLEDYFTSTEPQYQPGENL
3D structure
PDB5bmm Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D128 R130 A132 N133 D146 F166
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B L273 G274 Q275 G276 C277 G279 V281 K295 T296 L297 S345 L347 D386 R388 A390 L393 D404 A408 I411 L15 G16 Q17 G18 C19 G21 V23 K37 T38 L39 S87 L89 D128 R130 A132 L135 D146 A150 I153
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5bmm, PDBe:5bmm, PDBj:5bmm
PDBsum5bmm
PubMed27593110
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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