Structure of PDB 5b6i Chain B

Receptor sequence
>5b6iB (length=285) Species: 1400207 (Streptomyces sp. MA37) [Search protein sequence]
RPIIAFMSDLGTTDDSVAQCKGLMHSICPGVTVVDVCHSMTPWDVEEGAR
YIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIRQAAWAGSGDGFERAD
GSYIYIAPNNGLLTTVLEEHGYIEAYEVTSTKVIPANPEPTFYSREMVAI
PSAHLAAGFPLAEVGRRLDDSEIVRFHRPAVEISGEALSGVVTAIDHPFG
NIWTNIHRTDLEKAGIGQGKHLKIILDDVLPFEAPLTPTFADAGAIGNIA
FYLNSRGYLSLARNAASLAYPYNLKAGLKVRVEAR
3D structure
PDB5b6i Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native Substrate
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.63: adenosyl-fluoride synthase.
2.5.1.94: adenosyl-chloride synthase.
3.13.2.3: (R)-S-adenosyl-L-methionine hydrolase (adenosine-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MET B S23 T155 S16 T141
BS02 ADN B D16 W50 Y77 P78 T80 T155 F156 S158 D9 W43 Y70 P71 T73 T141 F142 S144
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0033846 adenosyl-fluoride synthase activity

View graph for
Molecular Function
External links
PDB RCSB:5b6i, PDBe:5b6i, PDBj:5b6i
PDBsum5b6i
PubMed27739177
UniProtW0W999|FLA_STRSQ Fluorinase (Gene Name=flA1)

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