Structure of PDB 5b49 Chain B

Receptor sequence
>5b49B (length=247) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
SVLFISDLHLEAERPDITRAFLSFLDERARRAEALYILGDFFEAWIGDDG
MDAFQRSIAQSLRQVADGGTRIYLMHGNRDFLIGKAFCREAGCTLLPDPS
VIDLYGEPVLLMHGDSLCTRDEAYMRLRRWLRNPLTLWVLRHLPLATRHK
LARKLRKESRAQTRMKAVDIIDVTPEEVPRVMRGHGVRTLIHGHTHRPAE
HPLDIDGQPARRIVLGDWDRQGWALEIDANGHRQAPFPLLEHHHHHH
3D structure
PDB5b49 Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa
ChainB
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.1.54: UDP-2,3-diacylglucosamine diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D8 H10 D41 H197 D7 H9 D40 H196
BS02 MN B D41 N79 H114 H195 D40 N78 H113 H194
BS03 LP5 B N79 R80 Y125 L156 R157 S160 T164 K167 H195 N78 R79 Y124 L155 R156 S159 T163 K166 H194
Gene Ontology
Molecular Function
GO:0008758 UDP-2,3-diacylglucosamine hydrolase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0051861 glycolipid binding
Biological Process
GO:0009245 lipid A biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0019897 extrinsic component of plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5b49, PDBe:5b49, PDBj:5b49
PDBsum5b49
PubMed27609419
UniProtQ9I2V0|LPXH_PSEAE UDP-2,3-diacylglucosamine hydrolase (Gene Name=lpxH)

[Back to BioLiP]