Structure of PDB 5b1s Chain B

Receptor sequence
>5b1sB (length=294) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
MPGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPK
GPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGG
VLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDG
LAFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCN
QGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKK
AGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN
3D structure
PDB5b1s In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease
ChainB
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S4M B Q64 Y73 H74 G95 D98 D118 I119 V123 D149 G150 D168 T169 T170 P175 A176 L179 Q64 Y73 H74 G95 D98 D118 I119 V123 D149 G150 D168 T169 T170 P175 A176 L179
BS02 BSX B W19 Q64 Y73 T169 T170 D171 Q201 Y237 W19 Q64 Y73 T169 T170 D171 Q201 Y237 MOAD: ic50=124uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
Biological Process
GO:0006596 polyamine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5b1s, PDBe:5b1s, PDBj:5b1s
PDBsum5b1s
PubMed28751689
UniProtQ4DA73

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