Structure of PDB 5awv Chain B

Receptor sequence

>5awvB (length=498) Species: 93944 (Nonomuraea gerenzanensis)

CLPPAGPVKVTPDDPRYLNLKLRGANSRFNGEPDYIHLVGSTQQVADAVE
ETVRTGKRVAVRSGGHCFEDFVDNPDVKVIIDMSLLTEIAYDPSMNAFLI
EPGNTLSEVYEKLYLGWNVTIPGGVCGGVGVGGHICGGGYGPLSRQFGSV
VDYLYAVEVVVVNKQGKARVIVATRERDDPHHDLWWAHTGGGGGNFGVVT
KYWMRVPEDVGRNPERLLPKPPATLLTSTVTFDWAGMTEAAFSRLLRNHG
EWYERNSGPDSPYTGLWSQLMIGNEVPGMGESGFMMPIQVDATRPDARRL
LDAHIEAVIDGVPPAEVPEPIEQRWLASTPGRGGRGPASKTKAGYLRKRL
TDRQIQAVYENMTHMDGIDYGAVWLIGYGGKVNTVDPAATALPQRDAILK
VNYITGWANPGNEAKHLTWVRKLYADVYAETGGVPVPNDVSDGAYINYPD
SDLADPGLNTSGVPWHDLYYKGNHPRLRKVKAAYDPRNHFHHALSIRP

3D structure

• PDB: 5awv Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
• Chain: B
• Resolution: 1.93 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	R202 H207 D208 R501 K504	R177 H182 D183 R476 K479
BS02	peptide	B	V150 C151 T254 Q294 G305 E306 P312 R357 W399	V125 C126 T229 Q269 G280 E281 P287 R332 W374
BS03	peptide	B	E438 A439 T443	E413 A414 T418
BS04	FAD	B	V86 R87 S88 G89 G90 H91 C92 F96 V97 G149 C151 V154 G155 G158 H159 Y165 G218 G219 V224 Y470 N472	V61 R62 S63 G64 G65 H66 C67 F71 V72 G124 C126 V129 G130 G133 H134 Y140 G193 G194 V199 Y445 N447
BS05	T55	B	M304 Y395 G431 W432	M279 Y370 G406 W407
BS06	N1L	B	F93 N427 Y473	F68 N402 Y448
BS07	MAN	B	P435 G436 E438 A439	P410 G411 E413 A414

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004497 monooxygenase activity
• GO:0016491 oxidoreductase activity
• GO:0016746 acyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0050660 flavin adenine dinucleotide binding
• GO:0071949 FAD binding

External links

• PDB: RCSB:5awv, PDBe:5awv, PDBj:5awv
• PDBsum: 5awv
• PubMed: 21478878
• UniProt: Q7WZ62