Structure of PDB 5ao1 Chain B

Receptor sequence
>5ao1B (length=443) Species: 9606 (Homo sapiens) [Search protein sequence]
MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPLEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDNPIDHVSFYCKT
APNRAIEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB5ao1 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainB
Resolution2.545 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DG3 B Y155 V156 V378 R451 Y41 V42 V260 R333
BS02 FE B H167 H206 D207 D311 H53 H92 D93 D193
BS03 DG3 B R164 H206 D207 H215 H233 D311 Y315 H370 Y374 R50 H92 D93 H101 H119 D193 Y197 H252 Y256
BS04 DG3 B K116 I118 D137 R145 K2 I4 D23 R31
External links
PDB RCSB:5ao1, PDBe:5ao1, PDBj:5ao1
PDBsum5ao1
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

[Back to BioLiP]