Structure of PDB 5ao0 Chain B

Receptor sequence
>5ao0B (length=435) Species: 9606 (Homo sapiens) [Search protein sequence]
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTIKIKR
EDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDHVSFYCKTAPNRAQ
LIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQD
3D structure
PDB5ao0 Phospho-Dependent Regulation of Samhd1 Oligomerisation Couples Catalysis and Restriction.
ChainB
Resolution3.731 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DG3 B Y155 V156 V378 R451 Y43 V44 V260 R333
BS02 FE B H167 H206 D207 D311 H55 H94 D95 D193
BS03 DG3 B R164 H206 D207 H215 H233 D311 Y315 Y374 R52 H94 D95 H103 H121 D193 Y197 Y256
BS04 DG3 B K116 V117 I118 D137 K4 V5 I6 D25
External links
PDB RCSB:5ao0, PDBe:5ao0, PDBj:5ao0
PDBsum5ao0
PubMed26431200
UniProtQ9Y3Z3|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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