Structure of PDB 5amm Chain B

Receptor sequence
>5ammB (length=267) Species: 5664 (Leishmania major) [Search protein sequence]
SEEPPFDIRALRADIEDMISEKLELGPSLIRLAWHEAASYDCFKKDGSPN
SASMRFKPECLYAGNKGLDIPRKALETLKKKYPQISYADLWVLAAYVAIE
YMGGPTIPFCWGRVDAKDGSVCGPDGRLPDGSKTQSHVREVFRRLGFNDQ
ETVALIGAHTCGECHIEFSGYHGPWTHNKNGFDNSFFTQLLDEDWVLNPK
VEQMQLMDRATTKLMMLPSDVCLLLDPSYRKYVELYAKDNDRFNKDFANA
FKKLTELGTRNLHKAPA
3D structure
PDB5amm Bind and Crawl" Association Mechanism of Leishmania Major Peroxidase and Cytochrome C Revealed by Brownian and Molecular Dynamics Simulations.
ChainB
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R64 H68 H192 W208 D253
Catalytic site (residue number reindexed from 1) R31 H35 H159 W175 D220
Enzyme Commision number 1.11.1.5: cytochrome-c peroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B P60 R64 W67 P162 G164 L188 A191 H192 E196 C197 H198 S202 W208 F284 P27 R31 W34 P129 G131 L155 A158 H159 E163 C164 H165 S169 W175 F251
BS02 CA B E69 S72 S81 E92 E36 S39 S48 E59
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress
GO:0034599 cellular response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:5amm, PDBe:5amm, PDBj:5amm
PDBsum5amm
PubMed26598276
UniProtQ4Q3K2

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