Structure of PDB 5agu Chain B

Receptor sequence
>5aguB (length=378) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DLTFRLLRESFADAVSWVAKNLPAVPVLSGVLLTGSDNGLTISGFDYEVS
AEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRVALTCGNA
RFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGRDDTLPML
TGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVPAKTLAEA
AKAGGGSDVRLSLGTGPGVGKDGLLGISGNGKRSTTRLLDAEFPKFRQLL
PTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRLSAGADDV
GRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTTAGKPALL
RPVSGDGNGPFPAVSTDYVYLLMPVRLP
3D structure
PDB5agu Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
ChainB
Resolution2.173 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B R183 F184 L264 M396 P397 V398 R399 R169 F170 L249 M373 P374 V375 R376
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
GO:0042802 identical protein binding
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009274 peptidoglycan-based cell wall
GO:0009360 DNA polymerase III complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5agu, PDBe:5agu, PDBj:5agu
PDBsum5agu
PubMed26045430
UniProtP9WNU1|DPO3B_MYCTU Beta sliding clamp (Gene Name=dnaN)

[Back to BioLiP]