Structure of PDB 5afq Chain B

Receptor sequence
>5afqB (length=444) Species: 9606 (Homo sapiens) [Search protein sequence]
MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQV
KKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYS
DTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVR
LADTHFVQRCPSVDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIV
RTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLAD
DPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFR
LVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMVNILSAARMLLHR
CYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIE
EMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMK
3D structure
PDB5afq Structural Analysis of Human Rpc32Beta - Rpc62 Complex.
ChainB
Resolution7.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H16 Y93 D510 H16 Y93 D422
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006359 regulation of transcription by RNA polymerase III
GO:0032728 positive regulation of interferon-beta production
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5afq, PDBe:5afq, PDBj:5afq
PDBsum5afq
PubMed26394183
UniProtQ9BUI4|RPC3_HUMAN DNA-directed RNA polymerase III subunit RPC3 (Gene Name=POLR3C)

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