Structure of PDB 5adz Chain B

Receptor sequence

>5adzB (length=542) Species: 10141 (Cavia porcellus) [Search protein sequence]

GIIPKKRQELMKWNGWGYNDSKFFLNKKGQLELTGKRYPLSGVALPTFKD
WIQNTFGINLTPPSIVNEDFLHELKKTNISYSQEADDRVFRAHGHCLHEI
FLLREGMFERIPDIVLWPTCHDDVVKIVNLACKYNLCIIPIGGGTSVSYG
LMCPADETRTIISLDTSQMNRILWVDENNLTAHVEAGITGQELERQLKES
GYCTGHEPDSLEFSTVGGWISTRASGMKKNIYGNIEDLVVHMKVVTPRGV
IEKSCQGPRMSTGPDIHHFIMGSEGTLGVITEATIKIRPTPEYQKYGSVA
FPNFEQGVACLREIAKQRCAPASIRLMDNQQFQFGHALKPGFDPNQLSVA
TLLFEGDREKVLQHEKQVYDIAAKFGGLAAGEDNGQRGYLLTYVIAYMRD
LGLEYYIIGESFETSAPWDRVVDLCRNVKERIRRECKEKGVQFPPLSTCR
VTQTYDAGACIYFYFAFNYRGISDPLAVFEQTEAAAREEILANGGSLSHH
HGVGKLRKQWLKESISDVGFGMLKSVKDYVDPTNIFGNRNLL

3D structure

PDB

5adz Discovery of Inhibitors for the Ether Lipid-Generating Enzyme Agps as Anti-Cancer Agents.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.26: alkylglycerone-phosphate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	W96 P234 I235 G236 G237 G238 T239 S240 V241 G244 L245 P302 D303 S304 S308 T309 G312 W313 S315 T316 A318 S319 E368 V373 I374 H616	W16 P140 I141 G142 G143 G144 T145 S146 V147 G150 L151 P208 D209 S210 S214 T215 G218 W219 S221 T222 A224 S225 E274 V279 I280 H500
BS02	KQS	B	R515 G525 E526 S527 Y578 H616 H617	R399 G409 E410 S411 Y462 H500 H501

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0008609	alkylglycerone-phosphate synthase activity
GO:0016740	transferase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding

	Biological Process
GO:0006629	lipid metabolic process
GO:0008610	lipid biosynthetic process
GO:0008611	ether lipid biosynthetic process

	Cellular Component
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5adz, PDBe:5adz, PDBj:5adz
PDBsum	5adz
PubMed	26322624
UniProt	P97275\|ADAS_CAVPO Alkyldihydroxyacetonephosphate synthase, peroxisomal (Gene Name=AGPS)

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