Structure of PDB 5abf Chain B

Receptor sequence
>5abfB (length=651) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
QVSLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGKQSS
KKGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTY
YALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLK
FYGKNKMNTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVD
FVWAIHPGQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNP
QKQAELLNYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKL
NPSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLL
LGPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQ
TWKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFL
KAFKEGKNYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQ
FKLTAEMGEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQ
PGVKTATRVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMLPLQVK
ANRVLISVEIELDAIYPGENIQINRLEISLSAGLQKAPVKFVRFQFVLTI
E
3D structure
PDB5abf A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable Oga Inhibitors.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E32 E61 D64 E31 E60 D63
BS02 XRJ B Y137 D242 D243 Y282 W286 W337 N339 D344 Y136 D241 D242 Y281 W285 W336 N338 D343 MOAD: Ki=14uM
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5abf, PDBe:5abf, PDBj:5abf
PDBsum5abf
PubMed26545827
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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