Structure of PDB 5ab9 Chain B

Receptor sequence
>5ab9B (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
SSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQ
LWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHL
IRVEGNLRAEYLDDRNTFRHSVVVPCEPPEVGSDCTTIHYNYMCYSSCMG
GMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRK
3D structure
PDB5ab9 Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.
ChainB
Resolution1.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C176 H179 C238 C242 C82 H85 C144 C148
BS02 92O B L145 V147 T150 C220 P223 T230 L51 V53 T56 C126 P129 T136 MOAD: Kd=470uM
BS03 92O B T150 P151 P153 C220 P222 T56 P57 P59 C126 P128 MOAD: Kd=470uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ab9, PDBe:5ab9, PDBj:5ab9
PDBsum5ab9
PubMed26636255
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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