Structure of PDB 5a86 Chain B

Receptor sequence
>5a86B (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRK
DLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGI
ISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRL
SYCLEDGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVL
QHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQH
TQRLLRIQDIHPFATPLMQELFGI
3D structure
PDB5a86 Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
ChainB
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I255 K259 I269 K277 P423 L424 E427 I101 K105 I115 K123 P266 L267 E270
BS02 D7E B L209 V211 M243 Q285 F288 W299 Y306 H327 L55 V57 M89 Q131 F134 W145 Y152 H170
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5a86, PDBe:5a86, PDBj:5a86
PDBsum5a86
PubMed26291341
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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