Structure of PDB 5a6k Chain B

Receptor sequence
>5a6kB (length=625) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
VRFTGLSLKQTQAIEVLKGHISLPDVEVAVTQSDQASISIEGEEGHYQLT
YRKPHQLYRALSLLVTVLAEADKVEIEEQAAYEDLAYMVDCSRNAVLNVA
SAKQMIEILALMGYSTFELYMEDTYQIEGQPYFGYFRGAYSAEELQEIEA
YAQQFDVTFVPCIQTLAHLSAFVKWGVKEVQELRDVEDILLIGEEKVYDL
IDGMFATLSKLKTRKVNIGMDEAHLVGLGRYLILNGVVDRSLLMCQHLER
VLDIADKYGFHCQMWSDMFFKLMSADGQYDRDVEIPEETRVYLDRLKDRV
TLVYWDYYQDSEEKYNRNFRNHHKISHDLAFAGGAWKWIGFTPHNHFSRL
VAIEANKACRANQIKEVIVTGWGDNGGETAQFSILPSLQIWAELSYRNDL
DGLSAHFKTNTGLTVEDFMQIDLANLLPDLPGNLSGINPNRYVFYQDILC
PILDQHMTPEQDKPHFAQAAETLANIKEKAGNYAYLFETQAQLNAILSSK
VDVGRRIRQAYQADDKESLQQIARQELPELRSQIEDFHALFSHQWLKENK
VFGLDTVDIRMGGLLQRIKRAESRIEVYLAGQLDRIDELEVEILPFTDFY
ADKDFAATTANQWHTIATASTIYTT
3D structure
PDB5a6k A Second Beta-Hexosaminidase Encoded in the Streptococcus Pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.52: beta-N-acetylhexosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NSG B R94 D222 E223 W266 W306 Y308 W339 W373 D375 R93 D221 E222 W265 W305 Y307 W338 W372 D374 MOAD: Ki=1130nM
PDBbind-CN: -logKd/Ki=5.95,Ki=1130nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563 beta-N-acetylhexosaminidase activity
GO:0015929 hexosaminidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5a6k, PDBe:5a6k, PDBj:5a6k
PDBsum5a6k
PubMed26491009
UniProtA0A0H2US73

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