Structure of PDB 5a2q Chain B

Receptor sequence
>5a2qB (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
VVDPFSKKDWYDVKAPAMFNIRNIGKTLVTRTQGTKIASDGLKGRVFEVS
LADLQNDEVAFRKFKLITEDVQGKNCLTNFHGMDLTRDKMCSMVKKWQTM
IEAHVDVKTTDGYLLRLFCVGFTKKRNNQIRKTSYAQHQQVRQIRKKMME
IMTREVQTNDLKEVVNKLIPDSIGKDIEKACQSIYPLHDVFVRKVKMLKK
PKFELGKLMELHG
3D structure
PDB5a2q Cryo-Em Structure of Hepatitis C Virus Ires Bound to the Human Ribosome at 3.9 Angstrom Resolution
ChainB
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B S112 V114 K115 K116 M120 R136 R146 N148 Q149 R151 Y155 Q157 H158 Q160 R162 R165 S203 I204 Y205 P206 K214 K216 S92 V94 K95 K96 M100 R116 R126 N128 Q129 R131 Y135 Q137 H138 Q140 R142 R145 S183 I184 Y185 P186 K194 K196
BS02 rna B N147 K167 N127 K147
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0048027 mRNA 5'-UTR binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0030154 cell differentiation
GO:0042274 ribosomal small subunit biogenesis
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5a2q, PDBe:5a2q, PDBj:5a2q
PDBsum5a2q
PubMed26155016
UniProtP61247|RS3A_HUMAN Small ribosomal subunit protein eS1 (Gene Name=RPS3A)

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